Information about HemoPyrrollactamUrie testing
The HPU-Test® is a screening test like the PKU-Test, which is better known as the heel prick test to determine which babies may later develop the disease Phenylketonuria (PHU). However the HPU-Test® is not carried out using blood, but urine. Similarly, the HPU-Test® can also determine which individuals may later develop symptoms of HemoPyrrollactamUrie.
HemoPyrrollactamUrie does not develop into a specific disease, but rather leads to a range of symptoms, from mild to very severe, such as joint complaints (hypermobility), menstrual complaints, reduced fertility, pelvic instability, depression, cardiovascular disease, anemia, diabetes, thyroid problems and excess weight gain during pregnancy. HemoPyrrollactamUrie is found mainly in women.
If you recognize yourself, even partially, in the pattern of symptoms that can be caused by HemoPyrrollactamUrie, you may ask yourself “Do I have HemoPyrrollactamUrie?” If you recognize the symptoms that can arise from direct vitamin B6, zinc and manganese deficiencies, it may be useful to find an answer to your question by further investigation.
In particular, increased joint mobility (hypermobility) is typical in people with HemoPyrrollactamUrie. Many women can extend their little finger backwards, or touch their lower arm with their thumb (see photo1 and photo 2). Hypermobility of the temporomandibular joint is also common. In addition, many women with HemoPyrrollactamUrie experience fatigue. Fatigue in HemoPyrrollactamUrie may be due to hypoglycaemia, reduced liver function, low histamine levels and/or adrenal function. As a result, countless women with fatigue issues consult medical and alternative health practitioners in search of a cure and are often incorrectly diagnosed or treated. An example is the ‘umbrella diagnosis’ chronic fatigue syndrome (CFS or ME). Some women given this diagnosis actually have HemoPyrrollactamUrie and can, therefore be treated accordingly.
If you would like to find out whether you have HemoPyrrollactamUrie, you can fill out the questionnaire that you find on this site.
HemoPyrrollactamUrie test options
HemoPyrrollactamUrie investigations consists of a number of test options. In addition to the HemoPyrrollactamUrie questionnaire on this website, the simplest option is to test the urine for the presence of the hydrohemopyrrollactam complex.
HPU screening
The HPU screening consists of multiple tests that are carried out using a blood sample. HPU screening consists of a fructosamine assay, a Zonulintest, a whole blood histamine assay, DAO and a simple hormone test. The costs of this blood test are € 188, -.
False positive results
Hydrohemopyrrolactam complex (HHPL) is excreted in the urine in most porphyria diseases, therefore it is possible that another porphyria disease may be present. The concentration of HHPL can be influenced by chemical load, but also by food. The highest concentration of HHPL in the urine is usually found several hours after a hot meal. Alcoholism, hyperthyroidism (increased thyroid processing) and mononucleosis (infectious disease with lymph node swelling) can influence the outcome.
The following diseases and conditions may increase the rash: pernicious anemia, Bartter’s syndrome, liver cirrhosis, Crigler-Najjar’s disease, Gilbert’s disease, hepatitis, spherocytosis, malaria, sickle cell disease, shortly after a heart attack, physical stress, psychological stress and shortly after operation or accident. In these cases, there is not necessarily a false-positive result.
Fals negative results
Your result may be false negative if you have regularly used vitamins, in particular B vitamins, zinc or manganese, in the form of multivitamins or mineral supplements. Following the use of such supplements, the quantity of HemoPyrrollactamUrie excreted gradually decreases. It will increase again during the period in which you avoid these supplements before your test, but it may not be sufficient to provide a positive result.
In general it can be assumed that, if you take more than 100mg of vitamin B6 over an extended period of time, you may expect a negative result, unless you are experiencing increased amounts of stress. .
Very specific drugs can negatively affect the amount of HHPL secreted. Anaemia from causes other than HemoPyrrollactamUrie, such as a deficiency in vitamin B12, sickle cell anaemia and reduced bilirubin levels may also resilt in lower concentrations of HHPL in the urine.
